Synthesis, characterization, and antibacterial evaluation of divalent metal complexes of Schiff base [(4-Methoxy- Benzylidene)- Amino]- Acetic acid

Abstract

A new Schiff base derived from 4-anisaldehyde and glycine in an ethanolic medium and its complexes with Co (II), Ni (II), Mn (II), and Cd (II) have been prepared. The complexes have been characterized by FTIR, solubility, melting/decomposition temperature determination, conductivity test, and Job’s method of continuous variation. The ligand was found to be bidentate as the metals coordinate with the ligand through the carboxylic oxygen and azomethine nitrogen. The in vitro antibacterial activity against Escherichia coli and Staphylococcus aureus strains was studied. The free ligand was found to have no biological activity against any of the strains.