Curcuma longa and punica granatum restore weight dysregulation and hematological alterations in wistar rats fed thermally oxidized oil

Abstract

Thermal abuse of oils has been linked to various health complications, including weight dysregulation and hematological alterations. This study aimed to investigate the potential restorative effects of turmeric and pomegranate supplementation on these disturbances in rats exposed to thermally abused oil. A total of 40 female rats were divided into eight (8) groups; a control group, a group exposed to thermally abused oil, three groups received supplementation of turmeric and/or pomegranate and three groups received a thermally abused oil-based diet supplemented with turmeric and/or pomegranate. The weight of rats was measured weekly and average weights were used for assessment of weight dysregulation. Hematological parameters, including WBC, lymphocytes, monocytes, neutrophils, eosinophil basophils, platelets and PVC were assessed using automated hematological analyzer. The result showed that turmeric and/or pomegranate restored normal weights in rats fed thermally abused oil (67.4%, 78.6% and 49.6% for the treatment groups compared to 98.6% of the thermally abused oil based diet group). The results also showed significant improvement (p<0.05) in the hematological parameters in the supplemented groups compared to the group exposed to thermally abused oil alone.. The study highlights the potentials of these natural supplements in mitigating oil-induced toxicity and promoting health in toxicological conditions.