Comparative Effects of Isolated ẞ-Caryophyllene and Duloxetine on Hematological Parameters in Oxaliplatin Induced Anemic Wistar Rats
Onwuka K. C.
Abstract
Oxaliplatin, an antineoplastic drug that offers a financial burden for patients coupled with an induced peripheral neuropathy, also presents an hematologic deficits such as anemia and neutropenia. However, researches have been ongoing for a cheaper and easily available natural substitute without incidence of pancytopenia. This study investigated the hematologic effects of beta-caryophyllene (BCP) fraction from Piper guineense in Wistar rats during oxaliplatin therapy. The rats used in this study were grouped into 5 groups (n=8). Except for normal control, all animals were treated with Oxaliplatin 4 mg/kg of body weight (b.w). Apart from the Negative control, rats were treated daily with Duloxetine 10 mg/kg b.w (control 3), BCP 25 mg/kg b.w (Group 4) and BCP at 50 mg/kg b.w(group 5). After three weeks of administration, the rats were analyzed for hematological parameters (P˂0.05). There were significant (P<0.05) decrease in red cell, hematocrit and white blood cell counts compared to BCP and duloxetine treated groups. However, there was no significant decrease in Platelet counts of group treated with oxaliplatin when compared to those treated with BCP and duloxetine. Oxaliplatin exerts anemic and leucopenic effects which could be ameliorated by BCP ad duloxetine. However, it is possible that it doesn’t cause thrombocytopenia in a sub-acute duration (21 weeks). Beta caryophyllene could offer erythropoietic effect in oxaliplatin therapy. The thrombocytopenia seen in clinical co-treatment of oxaliplatin with other drugs may not be a function of oxaliplatin.
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