Synthesis, Characterization, and Antibacterial Evaluation of Divalent Metal Complexes of Schiff Base [(4-Methoxy- Benzylidene)- Amino]- Acetic Acid
DOI: https://doi.org/10.33003/jobasr-2023-v1i1-19
Aisha Ibrahim Saulawa.
Abdullahi Hussaini Dangani.
Saudat Muhammad Abubakar.
Abstract
A new Schiff base derived from 4-anisaldehyde and glycine in an ethanolic
medium and its complexes with Co (II), Ni (II), Mn (II), and Cd (II) have been
prepared. The complexes have been characterized by FTIR, solubility,
melting/decomposition temperature determination, conductivity test, and Job’s
method of continuous variation. The ligand was found to be bidentate as the
metals coordinate with the ligand through the carboxylic oxygen and azomethine
nitrogen. The in vitro antibacterial activity against Escherichia coli and
Staphylococcus aureus strains was studied. The free ligand was found to have no
biological activity against any of the strains.
References
Agarwal, R., Asif Khan M. and Shamim, A. (2014).
Syntheses, characterization and Biological Activity of
some new Schiff base complexes derived from
thiosemicarbozone. Int. J. Recent Sci. Res, 4: 345.
Dharamraj, N., Viswanathanmurthi, P. and Natarajan, K.
(2001). Ruthenium (II) complexes containing bidentate
Schiff bases and their antifungal activity. Transit. Metal
Chem., 26:105–109.
Ejiah, F.N., Fasina, T.M., Familoni, O.B. and Ogunsola,
F. T. (2013) Substituent effect on spectral and
antimicrobial activity of Schiff bases derived from
aminobenzoic acids. Adv. Biol. Chem. 3:475–479.
Guidos, R.J. (2010). The 10×'20 Initiative: Pursuing a
Global Commitment to Develop 10 New Antibacterial
Drugs by 2020. Am. Clin. Infect. Dis. 50, 1081–1083.
Routier, S.,Vezin, H., Lamour, E., Bernier, J.L., Catteau,
J.P. and Bailly, C.(2000) DNA cleavage by hydroxysalicylidene-ethylendiamine-iron complexes. Nucleic
Acids Res., 27: 4160–4166.
Tarafder, M.T.H., Ali, M.A., Wee, D.J., Azahari, K.,
Silong, S. and Crowse, K.A. (2000). Complexes of a
tridentate ONS Schiff base. Synthesis and biological
properties. Transit.Metal Chem., 25: 456–460.
Valarmathy, G., Subbalakshmi, R., Selvameena, R. and
Gomathi, V. (2013). Synthesis, Characterisation and
Antimicrobial Screening of Mn(II), Co(II), Ni(II), Cu(II),
Zn(II), complexes with Schiff base derived from 2-
sulphanilamidopyridine and 2-hydroxy-3-
methoxybenzaldehyde. Asian Journal of Chemistry,
25(4): 2077-2079.
Shivakumar, K., Shashidhar, P., Vithal Reddy, P. and
Halli, M.B.(2008). Synthesis, spectral characterization
and biological activity of benzofuran Schiff bases with
Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II)
complexes. J. Coord. Chem. 61: 2274–2287.
PDF