Monovariation method was used to determine the M-L ratio of fluconazole (flz) and metformin (met) complexes of Cu. The stability constant of the formed complexes was calculated by conductance measurement using method of continuous variations. Thereafter, the Gibb’s free energy for the formation of Cu: flz and Cu: met complexes were evaluated accordingly. The conductometric titrations was carried out at 25 ℃. Data after the analysis showed the formation of 1:1 [M: L] ratio between Cu: flz and Cu: met; with stability constant of 3.39 and 2.25, respectively. The free energy change, -4.62 and -3.07 kCalmol¬-1 was obtained for Cu-flz and Cu-met, respectively. The negative values of ΔG means that the complexes formation process is spontaneous. This work has strongly revalidated previous claims and can be used in exploring more potential applications and enhancement of these drugs’ efficacies.

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